Organs-on-chips and Its Applications

Microfluidic chips have been proven to be attractive platforms for cell culture in vitro. Microfluidic chip-based organs-on-chips technology has received more attention because it can mimic the complex structures and functions of human organs. In this review, the recent advances of organs-on-chips technology in different organs are introduced, including the build of human physiological models, drug discovery, and toxicology research. The development trend of this technology is also proposed.

Graphical abstractOrgans-on-chips could produce fluid shear stress, mechanical stress, biochemical concentration gradient and other physical and chemical stimuli and precisely mimic the main function of many human organs. It has the potential to establish human physiological models and promote the development of drug discovery, and toxicology research.Figure optionsDownload full-size imageDownload as PowerPoint slide