| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1185795 | Food Chemistry | 2012 | 9 Pages |
Two new triterpenoids, garcinielliptones Q (1) and S (3), and a new phloroglucinol, garcinielliptone R (2), were isolated from the seed of Garcinia subelliptica. Their structures were established by analysis of their spectroscopic data. Phloroglucinol, garcinielliptone FC (4) from this plant exhibited a significant increase of antiproliferative effect, while 4 combined with cisplatin significantly caused decrease of cell inhibition induced by cisplatin in NTUB1. Exposure of NTUB1 cells to 4 cotreated with cisplatin for significantly decreased the amount of reactive oxygen species (ROS) than that of the total amount generated by 4 and cisplatin. These results suggested that 4 could protect the cisplatin toxicity through reduction of ROS in NTUB1. Phloroglucinols, garcinielliptones, A (5) and F (7), and garsubelline A (6), from this plant, revealed ABTS radical cation scavenging activity and 5 displayed an inhibitory effect on xanthine oxidase. These finding showed that 5–7 may be used as antioxidants.
► Two new triterpenoids and a new phloroglucinol were isolated from the seed of Garcinia subelliptica. ► Known phloroglucinols could protect the cisplatin toxicity through reduction of ROS in NTUB1 and identified as antioxidant. ► These findings showed that these constituents may be used as antioxidant.
