| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1185853 | Food Chemistry | 2009 | 5 Pages |
Abstract
Fucoidan extracted from the marine brown alga Undaria pinnatifida, significantly induced osteoblastic cell differentiation. Our results indicated that a non-toxic sulphated polysaccharide, fucoidan, can increase activity of alkaline phosphatase (ALP) and level of osteocalcin (OC) as phenotypic markers for early-stage osteoblastic differentiation and terminally osteoblastic differentiation, respectively. Furthermore, the results showed positive effects of fucoidan on bone morphogenic protein-2 (BMP-2) as an important factor for bone formation, remodeling and mineralization. The present study may provide new insights in the osteoblastic differentiation of fucoidan and possibility for its application in bone health supplement.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Young-Sook Cho, Won-Kyo Jung, Jung-Ae Kim, IL-Whan Choi, Se-Kwon Kim,