As, Hg, I, Sb, Se and Sn speciation in body fluids and biological tissues using hyphenated-ICP-MS techniques: A review

The present review deals with As, Hg, I, Sb, Se, and Sn speciation in biological tissues and body fluids carried out in the last ten years. The focus is inductively coupled plasma mass spectrometry (ICP-MS) as a powerful analytical tool for elemental speciation analysis. Methods based mainly on liquid chromatography–inductively coupled plasma mass spectrometry (LC–ICP-MS), gas chromatography–inductively coupled plasma mass spectrometry (GC–ICP-MS), capillary electrophoresis–inductively coupled plasma mass spectrometry (CE–ICP-MS) are highlighted. Applications of other hyphenated techniques are also included, but in lesser extent. Relevant applications of methodologies used for As, Hg, I, Se, Sb, and Sn speciation in biological tissues and body fluids are cited.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (223 K)Download as PowerPoint slideResearch highlights► Speciation analysis of As, I, Hg, Sb, Se, and Sn in biological materials is reviewed. ► Hyphenation of separation techniques with ICP-MS is discussed. ► New developments involving micro and nanoflow separation techniques are highlighted. ► Relevant applications are cited.