| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1196200 | Journal of the American Society for Mass Spectrometry | 2006 | 13 Pages |
Abstract
A MALDI ion source on a triple quadrupole mass spectrometer constructed for the purpose of obtaining high speed quantitative measurements on drugs and other low molecular weight compounds is described. Particular attention is given to the ion generation and transport phenomena that affect analysis speed, throughput, and practical instrument robustness. In this regard parameters that affect desorption speed, beam spreading, ion flight times, sensitivity, signal-to-noise, ion fragmentation, sample carry-over, and instrument contamination are examined and experimental results are provided. MALDI and electrospray sensitivity is compared, to provide a practical frame of reference.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jay J. Corr, Peter Kovarik, Bradley B. Schneider, Jan Hendrikse, Alexander Loboda, Thomas R. Covey,