Evaluation of center-cut separations applying simulated moving bed chromatography with 8 zones

•Estimation of 8 zone SMB operating space using the equilibrium model.•Efficient scanning algorithm based on a recursive solution of the TMB stage model.•Novel strategy for the calculation of outlet concentrations in ideal 8 zone TMB.•Analytical performance optimization of 8 zone TMB based on a profit function.•Definition of decision criteria for the optimal split sequence in 8 zone SMB.

Different multi-column options to perform continuous chromatographic separations of ternary mixtures have been proposed in order to overcome limitations of batch chromatography. One attractive option is given by simulated moving bed chromatography (SMB) with 8 zones, a process that offers uninterrupted production, and, potentially, improved economy. As in other established ternary separation processes, the separation sequence is crucial for the performance of the process. This problem is addressed here by computing and comparing optimal performances of the two possibilities assuming linear adsorption isotherms. The conclusions are presented in a decision tree which can be used to guide the selection of system configuration and operation.