Design, synthesis and evaluation of stationary phases for improved achiral supercritical fluid chromatography separations

•Highlights need for universal, achiral, stationary phase for SFC.•Details synthetic route of stationary phase preparation.•Examines effects of multipoint interaction in achiral SFC.•Provides an interesting discussion of test mix design from a pharmaceutical user's perspective.

A series of novel stationary phases for improved Supercritical Fluid Chromatography (SFC) separation of achiral mixtures is described. Several of these stationary phases show chromatographic performance and generality that is comparable with that of the best commercial stationary phases currently available. The effects of stationary phase structure on chromatographic performance and generality are considered, and suggestions for further improvements in this important field are offered.