Recent developments on polysaccharide-based chiral stationary phases for liquid-phase separation of enantiomers

This paper summarizes recent developments in the synthesis, application and mechanistic studies on polysaccharide-based chiral stationary phases (CSPs) for liquid phase separation techniques. Together with applications in conventional high-performance liquid chromatography (HPLC) applications in nano-liquid chromatography (nano-LC), capillary electrochromatography (CEC), super/sub-critical fluid chromatography (SFC) and preparative and product scale separations are also summarized. In the final part of the overview mechanistic aspects and some unusual effects observed in HPLC with these materials are shortly discussed and the author's view regarding future trends in this field is provided.

► Overview of the latest developments on polysaccharide-based CSPs. ► The applications of polysaccharide-based CSPs are summarized. ► The mechanistic aspects of separation of enantiomers in HPLC are discussed.