Chiral drug analysis using mass spectrometric detection relevant to research and practice in clinical and forensic toxicology

This paper reviews analytical approaches published in 2002–2012 for chiral drug analysis and their relevance in research and practice in the field of clinical and forensic toxicology. Separation systems such as gas chromatography, high performance liquid chromatography, capillary electromigration, and supercritical fluid chromatography, all coupled to mass spectrometry, are discussed. Typical applications are reviewed for relevant chiral analytes such as amphetamines and amphetamine-derived designer drugs, methadone, tramadol, psychotropic and other CNS acting drugs, anticoagulants, cardiovascular drugs, and some other drugs. Usefulness of chiral drug analysis in the interpretation of analytical results in clinical and forensic toxicology is discussed as well.

► Review of approaches for chiral drug analysis relevant in clinical and forensic toxicology. ► Discussion of the various separation systems coupled to mass spectrometry. ► Discussion of typical applications. ► Discussion of the usefulness of chiral analysis for clinical and forensic case interpretation.