Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1201822 | Journal of Chromatography A | 2011 | 4 Pages |
Abstract
(±)-Licarin A (1), a neolignan obtained by the oxidative coupling reaction of isoeugenol, had in this study its enantiomers resolved. A novel, quick and efficient enantiomeric resolution of 1 was directly performed by chiral high-performance liquid chromatography (HPLC-PDA) protocol (CHIRALPACK® AD column; 9:1 (v/v) n-hexane:2-propanol; 1.0 mL/min). This method provided a chromatogram profile with a well-resolved peak separation. After isolation of each enantiomer with ee > 99.9%, they were analysed in a polarimeter. Compound 2, which showed a retention time (tr) of 12.13 min, was the (+)-enantiomer and compound 3 (tr = 18.90 min) was the (−)-enantiomer.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ana Carolina Pereira, Lizandra G. Magalhães, Ana Helena Januário, Patrícia M. Pauletti, Wilson Roberto Cunha, Jairo Kenupp Bastos, Dhammika N.P. Nanayakkara, Márcio Luis A. e Silva,