Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1201969 | Journal of Chromatography A | 2011 | 7 Pages |
Abstract
A modified Equilibrium Dispersive (ED) Model is proposed for the modeling of chromatographic processes in columns packed with shell-particle adsorbents and operated under very high pressures. This new model was validated on the basis of experimental results obtained with 2.1 mm × 150 mm columns packed with superficially porous 1.7 μm Kinetex-C18 particles and with classical columns packed with 1.7 μm BEH-C18 fully porous particles. The influence of the heat friction on the performance of these columns was analyzed by comparing the experimental and calculated peak profiles. Moreover a theoretical analysis of the influence the solid-core conductivity on the column efficiency was discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Joanna Kostka, Fabrice Gritti, Krzysztof Kaczmarski, Georges Guiochon,