Article ID Journal Published Year Pages File Type
1202801 Journal of Chromatography A 2010 5 Pages PDF
Abstract

Two-step stacking of organic cations by sweeping and micelle to solvent stacking (MSS) in capillary zone electrophoresis (CZE) is presented. The simple procedure involves hydrodynamic injection of a micellar sodium dodecyl sulfate solution before the sample that is prepared without the micelles. The micelles sweep and transport the cations to the boundary zone between the sample and CZE buffer. The presence of organic solvent in the CZE buffer induces the second stacking step of MSS. The LODs obtained for the four beta blocker and two tricyclic antidepressant test drugs were 20–50 times better compared to typical injection.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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