| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1203043 | Journal of Chromatography A | 2012 | 8 Pages |
This paper demonstrates a combined approach for separating an active pharmaceutical ingredient (API) from a heavily contaminated waste stream. The approach uses organic solvent nanofiltration (OSN) to improve the application of counter-current chromatography (CCC) in an industrial process. OSN provides an efficient route for exchanging solutes from the process solvent into the desired mobile phase for CCC, generating a CCC feed containing less than 0.01% (area % by GC) of the original process solvents. The high solvent burden of CCC was additionally reduced through recovery of mobile phase using OSN, with the recovered solvent containing less than 1% (area % by HPLC) impurities. The recovered solvent was then successfully recycled into a subsequent CCC run with no indication of impurity build-up. Coupling OSN with CCC improved the mass-intensity of the CCC process, reducing the solvent use by 56%. OSN can be a useful tool in facilitating the application of CCC to pharmaceutical process streams.
► Combination of organic solvent nanofiltration and counter-current chromatography. ► Nanofiltration used for solvent exchange from process solvent to sample composition. ► Demonstrated feasibility for nanofiltration recovery and recycle of mobile phase. ► Benefits of approach proven in facilitated processing and improved mass-intensity.
