Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1205068 | Journal of Chromatography A | 2010 | 8 Pages |
Abstract
An exhaustive classification of matrix effects occurring when a sample preparation is performed prior to liquid-chromatography coupled to mass spectrometry (LC–MS) analyses was proposed. A total of eight different situations were identified allowing the recognition of the matrix effect typology via the calculation of four recovery values. A set of 198 compounds was used to evaluate matrix effects after solid phase extraction (SPE) from plasma or urine samples prior to LC–ESI-MS analysis. Matrix effect identification was achieved for all compounds and classified through an organization chart. Only 17% of the tested compounds did not present significant matrix effects.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ivano Marchi, Véronique Viette, Flavia Badoud, Marc Fathi, Martial Saugy, Serge Rudaz, Jean-Luc Veuthey,