| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1205320 | Journal of Chromatography A | 2010 | 23 Pages |
Abstract
This review considers some of the difficulties encountered with the analysis of ionised bases using reversed-phase chromatography, such as detrimental interaction with column silanol groups, and overloading which both lead to poor peak shapes. Methods of overcoming these problems in reversed-phase (RP) separations, by judicious selection of the column and mobile phase conditions, are discussed. Hydrophilic interaction chromatography is considered as an alternative method for the separation of some basic compounds.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
David V. McCalley,