| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1205526 | Journal of Chromatography A | 2009 | 5 Pages |
Abstract
The characterization of unknown impurities present in tobramycin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed-phase (RP)-LC method using a volatile mobile phase containing a perfluorinated ion-pair reagent was developed and coupled with an ion trap mass spectrometer. The structures of the unknown impurities were deduced by comparison of their fragmentation patterns with those of the available reference substances obtained by LC–MSn experiments.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
B. Li, A. Van Schepdael, J. Hoogmartens, E. Adams,