| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1205557 | Journal of Chromatography A | 2008 | 19 Pages |
Abstract
A total of 371 reversed-phase columns have now been characterized in terms of selectivity, based on five solute–column interactions (the hydrophobic-subtraction model). The present study illustrates the use of these data for interpreting peak-tailing and column stability. New insights are also provided concerning column selectivity as a function of ligand and silica type, and the selection of columns for orthogonal separations is re-examined. Some suggestions for the quality control of reversed-phase columns during manufacture are offered.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
D.H. Marchand, L.R. Snyder, J.W. Dolan,