Preparation of novel β-cyclodextrin chiral stationary phase based on click chemistry

A facile strategy based on click chemistry for preparation of the structurally well-defined native β-cyclodextrin (β-CD) based chiral stationary phase (CSP) was proposed. The β-CD CSP was evaluated by enatioseparation of benzoin, trans-stilbene oxide, Troger's base, bendroflumethiazide, ketoprofen, chlorthalidone, three flavanone compounds and two β-adrenergic blocking agents under reversed phase high performance liquid chromatography. The chromatographic results demonstrate the chiral separation ability of click β-CD CSP and illustrate the usefulness of click chemistry in the preparation of β-CD based CSP.