Article ID Journal Published Year Pages File Type
1205669 Journal of Chromatography A 2008 5 Pages PDF
Abstract

A microwave-assisted extraction (MAE) method has been developed and optimized for the extraction of six tricyclic antidepressants (TCAD; nordoxepin, nortriptyline, imipramine, amitriptyline, doxepin, dezypramine) from human serum. Optimal parameters of MAE (solvent and extraction temperature) for water solution of these drugs were defined. The microwave-assisted procedure developed was validated by extraction of serum samples at two concentration levels and then successfully applied to the analysis of reference material. Limit of quantification, precision and recovery were found for the studied compounds in the ranges 0.04–0.15 μg/mL, 1.57–4.34% (RSD) and 94–105%, respectively.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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