Article ID Journal Published Year Pages File Type
1207806 Journal of Chromatography A 2008 11 Pages PDF
Abstract
Microdialysis (MD) and solid-phase microextraction (SPME) methods have been developed and compared through in vitro and in vivo studies. For in vitro study, both methods offered accurate and precise results for complex sample matrices by standard addition method. Compared to MD, the fully automated SPME procedure offered several advantages including high-throughput and more efficient sampling, less labor intensity, and capability for batch analysis. For in vivo study, although both techniques provided sampling with minimal perturbation to the system under study, SPME was more sensitive, precise and accurate, suitable for field sampling and had a wider application than MD. It demonstrated that SPME has the potential to replace MD for in vivo study.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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