Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1207872 | Journal of Chromatography A | 2008 | 8 Pages |
Abstract
The present study reports on the exploration of the separation speed limits of RPLC chromatography in open-tubular channels. Applying the shear-driven chromatography principle in a 120-nm deep open channel, and using an improved detection set-up, the separation of three coumarin dyes was detectable 8 mm downstream of the injection point. At this distance, separation efficiencies of N = 17,900–24,100 plates were obtained at a velocity of 10 mm s−1, corresponding to a plate generation velocity of 21,100 to 28,300 plates per second for the most and least retained component, respectively.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Veronika Fekete, David Clicq, Wim De Malsche, Han Gardeniers, Gert Desmet,