Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1208301 | Journal of Chromatography A | 2008 | 5 Pages |
Abstract
In this paper, a new class of ligand-exchange chiral stationary phase (LE-CSP) based on the copper complexes of lipophilic aminoglycoside derivatives was reported. Different stationary phases were developed by coating reversed-phase liquid chromatography supports with three neamine derivatives carrying a lipophilic octadecyl chain at the 4′, 5 and 6 positions, respectively. The enantioselective ability of these LE neamine-based CSPs was evaluated and the 4′-derivative coated column was found to be the most interesting one for the amino acid resolution. The effects of the variation of several chromatographic parameters on the enantioseparation were evaluated in order to identify the analysis optimal conditions.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Mustapha Zaher, Isabelle Baussanne, Corinne Ravelet, Somnath Halder, Mohamed Haroun, Jennifer Fize, Jean-Luc Décout, Eric Peyrin,