| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1209074 | Journal of Chromatography A | 2006 | 8 Pages |
Abstract
This paper describes a strategy for the development of chromatographic methods for drug candidates based upon the use of simple MS compatible mobile phases and optimization of the chromatographic selectivity through variations of the stationary phase and mobile phase pH. The strategy employs an automated column selection system and a series of HPLC columns, varying in hydrophobicity and silanol activity, in combination with DryLab software to develop chromatographic methods for the separation of mixtures of bupivacaine and its metabolites; acidic, basic, and neutral compounds; and atenolol, nitrendipine, and their degradation products.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ryan M. Krisko, Kieran McLaughlin, Michael J. Koenigbauer, Craig E. Lunte,