Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1209596 | Journal of Chromatography A | 2006 | 7 Pages |
Abstract
A deep revision of the carbamate methyl derivatization reaction with sodium hydride/dimethyl sulfoxide/methyl iodide was carried out. Representative carbamates, R1–NH–COO–R2, mainly N-methyl and N-aryl ones, have been studied in order to clarify which carbamates undergo this reaction. Two possible reaction routes are proposed; the route depends on the carbamate substituent (–OR2 group) more than on the methyl or aryl groups joined to the NH moiety as literature indicates. The classification of carbamates in N-methyl and N-aryl is not suitable to predict the methylation pathway. A laboratory-made closed reactor allows handling the reagents involved, minimizing hazards and simplifying the procedure for rapid analysis.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
E. Crespo-Corral, M.J. Santos-Delgado, L. Mª Polo-Díez, J. Sanz-Perucha,