| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1210462 | Journal of Chromatography A | 2006 | 5 Pages |
Abstract
Solvent extractive two-phase menthoxycarbonyl (MnOC) derivatization was combined with trimethylsilyl (TMS) reaction for enantioseparation of β-blockers by gas chromatography employing achiral DB-5 and DB-17 dual-columns of different polarity. β-Blockers in alkaline solution were vortex-mixed with menthyl chloroformate present in dichloromethane to be extracted as diastereomeric N-MnOC derivatives. The subsequent O(N)-TMS reaction allowed complete enantioseparations of two β-blockers and partial separations of five as N-MnOC/O(N)-TMS derivatives in a single analysis. The temperature-programmed retention index sets were characteristic of each derivative, facilitating chiral discrimination of each enantiomer.
Keywords
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Man-Jeong Paik, Duc-Toan Nguyen, Kyoung-Rae Kim,