Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1210585 | Journal of Chromatography A | 2006 | 6 Pages |
Abstract
The direct HPLC enantioseparation of five pairs of new chiral pyrazole derivatives on coated cellulose- and amylose-based chiral stationary phases (Chiralpak AD, Chiralcel OJ and Chiralcel OJ-RH) and new immobilised amylose-based Chiralpak IA CSP was performed. Very high enantioselectivity factor (α) values were achieved in polar organic and reversed-phase conditions by using OJ-RH as CSP. Chiralpak IA exhibited an excellent chiral resolving ability in normal-phase mode and it allowed the enantioseparation of analytes investigated with resolution factors (Rs) >20. Due to its bonded nature, it was successfully employed at analytical and semipreparative scale in combination with normal-phase eluents containing “non-standards” solvents such as acetone.
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Authors
R. Cirilli, A. Simonelli, R. Ferretti, A. Bolasco, P. Chimenti, D. Secci, E. Maccioni, F. La Torre,