Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1210877 | Journal of Chromatography A | 2008 | 5 Pages |
Abstract
A sensitive and selective HPLC method with coulometric electrode array detection for the determination of pipecuronium bromide and its four impurities has been developed. The coulometric electrode array detection at increasing potentials from +300 to +900 mV of the porous graphite electrode versus the palladium reference electrode was used. The limit of detection and quantitation for pipecuronium bromide was 8 and 25 ng ml−1, respectively. This elaborate method for the simultaneous analysis of pipecuronium bromide and its impurities proved to be fast, precise, accurate, sensitive, and could be applied to analysis in substances and in pharmaceutical preparations.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Agata Błażewicz, Zbigniew Fijałek, Karolina Samsel,