Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1211030 | Journal of Chromatography A | 2007 | 8 Pages |
Abstract
A database for preliminary identification and quantification of residual solvents in pharmaceuticals has been established using the parallel dual-column system. Two columns with different polarities, SPB-1 and HP-INNOWAX, connected with a 'Y' splitter, constituted the dual pathways system. Fifty-two solvents were studied according to the guidelines for residual solvents regulated by the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) on this system. Through a single run, preliminary identification and quantification can be performed using the database. An important advantage of the database is that the residual solvents in the pharmaceuticals can be prescreened without using reference organic solvents.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ying Liu, Chang-Qin Hu,