Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1211069 | Journal of Chromatography A | 2007 | 15 Pages |
Abstract
Using a combination of both analytical and numerical techniques, approximate analytical expressions have been established for the transient and long time limit band broadening, originating from the presence of a thin disturbed sidewall layer in liquid chromatography columns, including packed, monolithic as well as microfabricated columns. The established expressions can be used to compare the importance of a thin disturbed sidewall layer with that of other radial heterogeneity effects (such as transcolumn packing density variations due to the relief of packing stresses). The expressions are independent of the actual velocity profile inside the layer as long as the disturbed sidewall layer occupies less than 2.5% of the column width.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ken Broeckhoven, Gert Desmet,