Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1211129 | Journal of Chromatography A | 2007 | 12 Pages |
Abstract
The design of simulated moving bed chromatography under reduced purity requirements is investigated. A parametric study indicates that all internal flow rates should be considered as free parameters in process design. This is confirmed by systematic numerical optimisations of two different design scenarios. A restrictive scenario requires complete regeneration of liquid and solid phases. In contrast, in a non-restrictive design all flow rates are optimised. The latter leads to significantly improved process performance. On the basis of the obtained observations, a simple design method for simulated moving bed processes with desired outlet purity values is derived from equilibrium theory.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Malte Kaspereit, Andreas Seidel-Morgenstern, Achim Kienle,