Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation

In this study, ester-bond biphenyl cyclooctene lignans were efficiently hydrolytically degraded into free biphenyl cyclooctene lignans by ion exchange resin transformation and simultaneous removal of impurities by macroporous resin. The OH-type strongly basic anion exchange resin 201 × 7 was the best one, and the dynamic hydrolysis efficiency was 146.7 ± 5.0%. HPD5000 macroporous resin, which offered higher adsorption and desorption capacities and faster adsorption than other resins. The purity of free biphenyl cyclooctene lignans in the product increased from 5.14 ± 0.24% to 79.67 ± 0.0.67%. After dynamic catalytic transformation by 201 × 7 resin combined with purification of HPD5000 resin, the yield and the purity of free biphenyl cyclooctene lignans in the product were 132.1 ± 4.7% and 80.91 ± 3.53%, respectively.

► Analysis of four kinds of biphenyl cyclooctene lignans by LC–ESI-MS simultaneously. ► Hydrolysis ester-bound lignans by ion exchange resin instead of inorganic catalyst. ► The adsorption isotherm analysis by Langmuir and Freundlich model simultaneously.