Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1213468 | Journal of Chromatography B | 2012 | 6 Pages |
Abstract
⺠A selective, rapid and sensitive UPLC/MS method was developed and validated to quantitate a highly selective mixed-affinity sigma receptor ligand. ⺠The validated analytical method resulted in a run time of 4 min. The calibration curve exhibited excellent linearity over a concentration range of 5-4000 ng/mL (LLOQ, 5 ng/mL). The intra- and inter-day precision values were below 15% and accuracy ranged from â6.5% to 5.0%. ⺠The validated method was successfully applied to an intravenous pharmacokinetic study of CM156 in rats.
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Authors
Seshulatha Jamalapuram, Pradeep K. Vuppala, Christophe Mesangeau, Christopher R. McCurdy, Bonnie A. Avery,