Article ID Journal Published Year Pages File Type
1214227 Journal of Chromatography B 2011 6 Pages PDF
Abstract

Detection of d-amino acids in natural peptides has been, and remains a challenging task, as peptidyl isomerization is a peculiar and subtle posttranslational modification that does not induce any change in primary sequence or in physicochemical properties of the molecule such as molecular mass or pI. Therefore, the presence of a d-amino acid residue in a peptide chain is generally transparent to classical methods of peptide analysis (electrophoresis, chromatography, mass spectrometry, molecular biology). In this article, we will review the various experimental strategies and analytical techniques, which have been used to characterize and to study d-amino acid containing peptides in crustaceans.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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