| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1214368 | Journal of Chromatography B | 2010 | 5 Pages |
Abstract
A simple and reproducible high performance liquid chromatography–tandem mass spectrometric method was developed for methocarbamol analysis in human plasma. Methocarbamol and the internal standard (IS) were extracted by a protein precipitation method. Under isocratic separation condition the chromatographic run time was 3.0 min. The calibration curve was linear over a range of 150–12,000 ng/mL with good intraday assay and interday assay precision (CV% < 10.9%). The method was proven to be sensitive and selective for the analysis of methocarbamol in human plasma for bioequivalence study.
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Authors
Wuyi Zha, Zhimeng Zhu,