| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1214796 | Journal of Chromatography B | 2009 | 7 Pages |
Abstract
Organophosphorus flame retardants (OPFR), phosphorus triesters, are widely used chemicals with a high share of the worldwide flame retardant market. In animal experiments, dialkyl- and diarylphosphates are the main metabolites of OPFR. Therefore we elaborated a GC–MS/MS-method for the detection of OPFR-metabolites in human urine after solid phase extraction and derivatization with pentafluorobenzylbromide. The limits of detection range from 0.1 to 1 μg/l. Interday imprecision were 2–8%. The applicability of the method is shown by determination of the internal burden of 30 persons of the German general population. OPFR-metabolite concentrations range from
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Authors
Birgit Karin Schindler, Katrin Förster, Jürgen Angerer,