| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1214889 | Journal of Chromatography B | 2008 | 6 Pages |
Abstract
Bis(p-fluorobenzyl)trisulfide (BFTS) demonstrated a broad spectrum of anti-proliferative activity and in vivo anti-tumor efficacy in human xenograft mice models. BFTS is rapidly degraded to its major metabolite bis(p-fluorobenzyl)disulfide (BFDS) in blood. In this study, we developed a reliable procedure for stable storage and treatment of blood samples containing BFTS. An HPLC assay method was developed and validated for the quantitative determination of BFTS and BFDS in rat blood. The developed procedure and method have been successfully utilized to study the concentration–time curves of BFTS and BFDS in the blood of rats after vein injection of 12.5 mg kg−1 BFTS.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Liqiang Gu, Liping Li, Zhongjian Chen, Hao Pan, Huidi Jiang, Su Zeng, Xiao Xu, Haoyun An,