Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1214901 | Journal of Chromatography B | 2010 | 7 Pages |
Abstract
High quality, ultra-fast bioanalytical LC/MS/MS methods were developed using short columns packed with fused-core particles and high (1.0–3.0 mL/min) flow rates. For more than two years, at flow rates up to 3.0 mL/min, using 0.33 min non-ballistic gradients, these methods were shown to provide comparable or better performance than slower assays for accuracy, precision, sensitivity, specificity, and ruggedness, and met all criteria required by the bioanalytical regulatory guidance.
Related Topics
Physical Sciences and Engineering
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Analytical Chemistry
Authors
Ethan R. Badman, Richard L. Beardsley, Zhenmin Liang, Surendra Bansal,