| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1215361 | Journal of Chromatography B | 2010 | 5 Pages |
Abstract
Surface plasmon resonance (SPR) permits the quantitative analysis of therapeutic antibody concentrations and impurities including bacteria, Protein A, Protein G and small molecule ligands leached from chromatography media. The use of surface plasmon resonance has gained popularity within the biopharmaceutical industry due to the automated, label free, real time interaction that may be exploited when using this method. The application areas to assess protein interactions and develop analytical methods for biopharmaceutical downstream process development, quality control, and in-process monitoring are reviewed.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Pranavan Thillaivinayagalingam, Julien Gommeaux, Michael McLoughlin, David Collins, Anthony R. Newcombe,