Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1215435 | Journal of Chromatography B | 2007 | 7 Pages |
Abstract
Changes in the molecular species of lipids associated with Pex2 gene-mutation were investigated to elucidate the pathogeneses of peroxisome biogenesis disorders. Although no differences were observed in the concentrations of cholesterol and phosphatidyl choline between mutated Z65 and control CHO-K1 cells, the amounts of cholesterol esters and glycolipids in Z65 cells were twice those in CHO-K1 cells, but phosphatidyl ethanolamine (PE), particularly 1-O-octadec-1′-enyl-2-oleoyl PE, was absent in Z65 cells by FABMS. Enhanced synthesis of glycolipids in Z65 cells was associated with an abundance of lignoceric acid-containing ones, suggesting a role of glycolipids in the retention of longer saturated fatty acids.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Makiko Saito, Makoto Horikawa, Yuriko Iwamori, Yoichi Sakakihara, Masashi Mizuguchi, Takashi Igarashi, Yukio Fujiki, Masao Iwamori,