Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1215473 | Journal of Chromatography B | 2007 | 6 Pages |
Abstract
A method for the determination of pindolol enantiomers in amniotic fluid and breast milk was developed, validated, and applied to the investigation of six pregnant women treated with rac-pindolol (10Â mg/12Â h). Biological samples were extracted with tert-methyl-butyl ether, and the pindolol enantiomers were resolved on a Chiralpak AD column. Amniotic fluid/plasma and milk/plasma concentrations ratios ranged from 0.4 to 4.5 and from 0.6 to 3.7, respectively, for (+)-R-pindolol and from 0.5 to 3.5 and from 1.1 to 2.8, respectively, for (â)-S-pindolol. Preliminary data suggest that amniotic fluid and breast milk are routes of fetal exposure to pindolol enantiomers.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Paulo Vinicius Bernardes Gonçalves, Ricardo Carvalho Cavalli, Sergio Pereira da Cunha, Vera Lucia Lanchote,