| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1215803 | Journal of Chromatography B | 2009 | 5 Pages |
Abstract
A rapid HPLC method using a monolithic column with fluorescence detection has been developed for determination of telmisartan in human plasma. Sample preparation was done by protein precipitation with acetonitrile and naproxen was used as IS. The compounds were detected by fluorescence detection, using an excitation wavelength of 300 nm and emission wavelength of 385 nm. Calibration curves of telmisartan were linear in the range of 1–200 ng/mL. The assay was high throughput, sensitive and precise, and it was successfully applied to a bioequivalence study of two formulations of telmisartan.
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Authors
He Zhang, Yunyun Jiang, Jun Wen, Tingting Zhou, Guorong Fan, Yutian Wu,