Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1216182 | Journal of Chromatography B | 2007 | 16 Pages |
Abstract
Many different methodologies have been applied for the detection of S-nitrosothiols (RSNOs) in human biological fluids. One unsatisfactory outcome of the last 14 years of research focused on this issue is that a general consensus on reference values for physiological RSNO concentration in human blood is still missing. Consequently, both RSNO physiological function and their role in disease have not yet been clarified. Here, a summary of the values measured for RSNOs in erythrocytes, plasma, and other biological fluids is provided, together with a critical review of the most widely used analytical methods. Furthermore, some possible methodological drawbacks, responsible for the highlighted discrepancies, are evidenced.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Daniela Giustarini, Aldo Milzani, Isabella Dalle-Donne, Ranieri Rossi,