| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1216185 | Journal of Chromatography B | 2007 | 12 Pages |
Abstract
The permanent modification of soluble and protein-associated tyrosine by nitration results in the formation of 3-nitrotyrosine, which can be used as a marker of “nitro-oxidative” damage to proteins. Based on the analysis of patient materials, over 40 different diseases and/or conditions have been linked to increased nitration of tyrosine. They include many cardiovascular diseases, conditions associated with immunological reactions and neurological diseases. In this article we review the existing chromatographic and mass spectrometric methods for quantitative measurements of 3-nitrotyrosine in different human biological samples including plasma, either from the free amino acid pool or from hydrolyzed proteins from different matrices.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Henrik Ryberg, Kenneth Caidahl,