| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1216733 | Journal of Chromatography B | 2006 | 4 Pages |
Abstract
A simple HPLC assay to determine plasma concentration of tipranavir is presented. A liquid/liquid extraction of the drugs in ethyl acetate/hexane from 250 μL of plasma is followed by a reversed phase isocratic HPLC assay with UV detection at 205 nm. The imprecision and inaccuracy are lower than 10%, the low limit of quantitation is 0.4 mg/L. Thus, this method can be used for therapeutic drug monitoring of tipranavir in HIV infected patients
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
E. Dailly, V. Reliquet, C. Victorri-Vigneau, F. Raffi, P. Jolliet,