Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1216822 | Journal of Chromatography B | 2006 | 4 Pages |
Abstract
A rapid and simple HPLC assay was developed for the determination of celecoxib in human plasma and breast milk. After proteins were precipitated with acetonitrile, celecoxib was resolved on a C18 column and detected by UV detection at 254 nm. Standard curves were linear over the concentration range 10–2000 μg/L (r2 > 0.99). Bias was ≤±15% from 20 to 2000 μg/L in both matrices, intra- and inter-day coefficients of variation (imprecision) were <10%, and the limit of quantification was 10 μg/L.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Mei Zhang, Grant A. Moore, Sharon J. Gardiner, Evan J. Begg,