Article ID Journal Published Year Pages File Type
1216822 Journal of Chromatography B 2006 4 Pages PDF
Abstract

A rapid and simple HPLC assay was developed for the determination of celecoxib in human plasma and breast milk. After proteins were precipitated with acetonitrile, celecoxib was resolved on a C18 column and detected by UV detection at 254 nm. Standard curves were linear over the concentration range 10–2000 μg/L (r2 > 0.99). Bias was ≤±15% from 20 to 2000 μg/L in both matrices, intra- and inter-day coefficients of variation (imprecision) were <10%, and the limit of quantification was 10 μg/L.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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