| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1217027 | Journal of Chromatography B | 2012 | 7 Pages |
Abstract
⺠A fast and sensitive radio-LC method have developed and validated for a wide array of PET radioligands. ⺠The method has an LOD of 1 Bq for 11C-labeled radioligands with good temporal resolution (3.5 min) and improved sample loadability (1.5-2.0 mL plasma). ⺠This characteristic enables higher numbers of samples (up to 24 samples per PET measurement) to be analyzed compared to conventional method. ⺠This method can successfully be applied to study the metabolism of PET radioligands in human and monkey plasma.
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Authors
Ryuji Nakao, Magnus Schou, Christer Halldin,