| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1217189 | Journal of Chromatography B | 2007 | 5 Pages |
Abstract
The capability of biopartitioning micellar chromatography (BMC) to describe and estimate pharmacological parameters of cardiovascular system drugs has been studied. The retention of cardiovascular system drugs was studied using different pH of Brij-35 as micellar mobile phase in modified C18 stationary phase. Quantitative retention–activity relationships (QRAR) in BMC were investigated for these compounds. An adequate correlation between the retention factors (log k) and the toxicity (LD50) of cardiovascular system drugs was obtained.
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Authors
Sumin Wang, Gengliang Yang, Hua Zhang, Haiyan Liu, Zhiwei Li,