Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1217858 | Journal of Chromatography B | 2007 | 12 Pages |
Abstract
Proteomics relies on the separation of complex protein mixtures using bidimensional electrophoresis. This approach is largely used to detect the expression variations of proteins prepared from two or more samples. Recently, attention was drawn on the reliability of the results published in literature. Among the critical points identified were experimental design, differential analysis and the problem of missing data, all problems where statistics can be of help. Using examples and terms understandable by biologists, we describe how a collaboration between biologists and statisticians can improve reliability of results and confidence in conclusions.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jean-François Chich, Olivier David, Fanny Villers, Brigitte Schaeffer, Didier Lutomski, Sylvie Huet,