| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1220758 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 9 Pages |
Abstract
- A case study of transition metal-induced drug dimerization in HPLC analysis.
- Structures of two pseudo-dimeric degradants were elucidated.
- Degradation by transition metal-induced single electron transfer oxidation.
- Transition metal could arise from either stainless steel column frits or tubing.
- Procedures to prevent transition metal-induced drug degradation were discussed.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Qinggang Wang, Brian Lingfeng He, Jin Zhang, Yande Huang, Brent Kleintop, Thomas Raglione,