| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1220844 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 5 Pages |
•We identify two degradation products of cefoselis sulfate (CSS).•We estimate influence temperature and relative air humidity (RH) on the stability of CSS.•We calculate kinetic and thermodynamic parameters of degradation of CSS.•We compare stability of CSS with cefozopran (CZH) and cefpirome (CPS).
The process of degradation was studied by using an HPLC–DAD method. Two degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefoselis sulfate was investigated. In the solid state at increased RH the degradation of cefoselis sulfate was an autocatalytic reaction of the first order with respect to substrate concentration while in dry air was first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
